The Gunners are on 14 points after six games into the campaign and have the chance to go top with a huge win if Liverpool drop points at Crystal Palace.
Ahead of the game, Jurrien Timber, Ben White and Takehiro Tomiyasu are likely to undergo fitness tests. None of them may start in our opinion.
Formation: 4-4-2
Predicted Line-up:
David has been ever-present in the Premier League this term with three clean sheets. He will be eyeing another shut-out against the Saints.
The backline should witness a change with Jurrien Timber nursing a minor muscular issue. He was left out of the Nations League squad by Netherlands for the same reason.
With White and Tomiyasu just returning from injury, Riccardo Calafiori could be asked to continue at right-back with Jakub Kiwior operating from the left side of the back four.
William Saliba and Gabriel Magalhaes are expected to feature in central defence and the same can be said about Thomas Partey and Declan Rice in the heart of the Gunners midfield.
The frontline should stay the same too. Bukayo Saka and Gabriel Martinelli are set to feature out wide with Leandro Trossard partnering Kai Havertz up front in a two-striker partnership.
Havertz has netted in six straight home games and should fancy another goal against one of the leakiest defences in the Premier League.
Predicted Arsenal line-up (4-4-2): Raya; Calafiori, Saliba, Gabriel, Kiwior; Partey, Rice; Saka, Martinelli; Trossard, Havertz.